Encoding of natural variability in a dexterous motor skill over multiple days in the cortex of freely behaving mice
de Laittre, E. A.; MacLean, J. N. · neuroscience · 2026-09-06 · 原文
DOI：10.1101/2024.12.20.629771作者：2 位
Skilled, goal-directed movements exhibit trial-to-trial variability even in experts, particularly in response to dynamic environmental conditions or when perfect repetition is not required for success. Identifying where, to what extent, and how stably this variability is encoded in the nervous system is essential for understanding how learned movements are robustly maintained over time yet flexibly executed on each trial. We record calcium fluorescence activity in forelimb motor cortex (M1), a key node in the multi-areal network responsible for movement control, in freely-moving mice of both sexes as they performed a self-paced, precision reach-to-grasp task. High trial counts and rich single-trial variability enable rigorous statistical analysis of moment-to-moment movement encoding across matched behavioral sets over five days. Approximately 80% of recorded neurons significantly encoded paw, digit, and head movements during reaching, as quantified using linear models. Across days, encoding similarity shows a small but measurable decline that increases with the interval between recording sessions. This drift is heterogeneously distributed across the population, with many neurons r
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1. 人话版
Skilled, goal-directed movements exhibit trial-to-trial variability even in experts, particularly in response to dynamic environmental conditions or when perfect repetition is not required for success.
Identifying where, to what extent, and how stably this variability is encoded in the nervous system is essential for understanding how learned movements are robustly maintained over time yet flexibly executed on each trial.
2. 领域脉络
本文类目：neuroscience，属于其所在研究脉络的最新进展。
3. 机制拆解
High trial counts and rich single-trial variability enable rigorous statistical analysis of moment-to-moment movement encoding across matched behavioral sets over five days.
4. 证据与数字
We record calcium fluorescence activity in forelimb motor cortex (M1), a key node in the multi-areal network responsible for movement control, in freely-moving mice of both sexes as they performed a self-paced, precision reach-to-grasp task.
Approximately 80% of recorded neurons significantly encoded paw, digit, and head movements during reaching, as quantified using linear models.
5. 反例与边界
Across days, encoding similarity shows a small but measurable decline that increases with the interval between recording sessions.
This drift is heterogeneously distributed across the population, with many neurons r
6. 跨领域连接与意外收获
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