A Na+-selective receptor enables state-dependent plasticity in high-salt taste
Qu, G.; Wang, B.; Chen, Y. · neuroscience · 2026-09-07 · 原文
DOI：10.1101/2025.10.07.680871作者：3 位
Sodium is an essential ion, but harmful in excess. Animals must suppress sodium aversion during deficiency, yet a cation-nonselective override would expose them to other harmful salts. Whether and how the sensory periphery regulates high-salt taste to achieve Na+-specific tuning remains unknown. Here we identify a Na+-selective, state-tunable high-salt detection mechanism in Drosophila. IR11a and IR25a function in bitter gustatory receptor neurons (GRNs) and are required for aversion specifically to high Na+. Loss of IR11a abolishes responses to Na+ and Li+ while sparing detection of K+, Ca2+, and bitter compounds. Heterologous expression confirms that IR11a and IR25a together confer Na+ responsiveness. During sodium deprivation, Na+ sensitivity in IR11a-expressing neurons is decreased and restored upon satiety, allowing flies to attenuate Na+ aversion specifically. The IR7c-dependent nonselective mechanism remains insensitive to sodium deprivation, thereby preserving aversion to other noxious cations even during sodium deficiency. The IR11a-mediated response is amiloride-sensitive, a functional signature reminiscent of mammalian ENaC despite the absence of sequence homology. This
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1. 人话版
Sodium is an essential ion, but harmful in excess.
Animals must suppress sodium aversion during deficiency, yet a cation-nonselective override would expose them to other harmful salts.
2. 领域脉络
本文类目：neuroscience，属于其所在研究脉络的最新进展。
3. 机制拆解
Whether and how the sensory periphery regulates high-salt taste to achieve Na+-specific tuning remains unknown.
Here we identify a Na+-selective, state-tunable high-salt detection mechanism in Drosophila.
4. 证据与数字
IR11a and IR25a function in bitter gustatory receptor neurons (GRNs) and are required for aversion specifically to high Na+.
Loss of IR11a abolishes responses to Na+ and Li+ while sparing detection of K+, Ca2+, and bitter compounds.
Heterologous expression confirms that IR11a and IR25a together confer Na+ responsiveness.
5. 反例与边界
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6. 跨领域连接与意外收获
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7. 可复用方法
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8. 术语表
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