Comparison of the Distribution of Fitness Effects Across Primates
Sendrowski, J.; Pedersen, B. M.; Bergman, J.; Pankratov, V.; Bataillon, T. · evolutionary biology · 2026-09-06 · 原文
DOI：10.64898/2026.03.25.714151作者：5 位
The distribution of fitness effects (DFE) of mutations is a key determinant of both the efficacy of natural selection and the genetic load of populations. It also provides an indirect summary of the underlying fitness landscape, so the extent to which the DFE is conserved across species is informative about the invariance of those landscapes. Here, we infer the DFE of amino-acid-changing mutations in 38 catarrhine subspecies using site-frequency spectrum (SFS)-based methods. We find that effective population size (Ne) is the dominant axis of cross-species variation in the population-scaled DFE for deleterious mutations, with the apparent clade-level clustering of estimates explained mainly by shared Ne rather than by clade-specific effects. A quantile-based test further shows that the underlying unscaled DFE does not vary significantly across species, so differences are consistent with Ne-rescaling of a single conserved DFE. Consistent with this, the deleterious (non-adaptive) substitution rate {omega}na declines significantly with Ne, reflecting more efficient purging of slightly deleterious mutations in larger populations. Turning to adaptive substitution, we find weaker, suggest
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1. 人话版
The distribution of fitness effects (DFE) of mutations is a key determinant of both the efficacy of natural selection and the genetic load of populations.
It also provides an indirect summary of the underlying fitness landscape, so the extent to which the DFE is conserved across species is informative about the invariance of those landscapes.
2. 领域脉络
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3. 机制拆解
We find that effective population size (Ne) is the dominant axis of cross-species variation in the population-scaled DFE for deleterious mutations, with the apparent clade-level clustering of estimates explained mainly by shared Ne rather than by clade-specific effects.
A quantile-based test further shows that the underlying unscaled DFE does not vary significantly across species, so differences are consistent with Ne-rescaling of a single conserved DFE.
4. 证据与数字
Here, we infer the DFE of amino-acid-changing mutations in 38 catarrhine subspecies using site-frequency spectrum (SFS)-based methods.
5. 反例与边界
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