Assessing nonlinear associations between body mass index and brain microstructure across adolescence in the ABCD Study
Rigby, A.; Pecheva, D.; Parekh, P.; Smith, D. M.; Becker, A.; Linkersdoerfer, J.; Watts, R.; Loughnan, R.; Hagler, D. J.; Rhee, K. E.; Makowski, C.; Dale, A. M.; Jernigan, T. L. · neuroscience · 2026-09-04 · 原文
DOI：10.64898/2026.04.02.716201作者：13 位
Importance: Adolescent body mass index (BMI) is linked to brain microstructural alterations, but it is not known if this association is uniform across the BMI range. Objective: To characterize the shape of the association between adolescent BMI and brain microstructure across the BMI range. Design: Baseline, and 2-, 4-, and 6-year follow-up brain imaging and BMI from the Adolescent Brain Cognitive DevelopmentSM Study, analyzed between June 2025 and June 2026. Setting: Multicenter, population-based study including 21 sites distributed across the US. Participants: 10,479 adolescents (5,078 [48.5%] female; aged 9-18 years) from this population-based cohort study were included after quality control of complete data. Exposures: Centers for Disease Control BMI extended percentiles and percent from median BMI. Main Outcome and Measure: The primary outcome was the restricted normalized isotropic (RNI) signal fraction derived from diffusion imaging which indexes water confined within spherical cellular structures and is sensitive to microstructural properties including cellularity. Results: A total of 10,479 participants (5,078 [48.5%] female; aged 9-18 years) contributed 22,049 imaging obs
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1. 人话版
Importance: Adolescent body mass index (BMI) is linked to brain microstructural alterations, but it is not known if this association is uniform across the BMI range.
Objective: To characterize the shape of the association between adolescent BMI and brain microstructure across the BMI range.
2. 领域脉络
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3. 机制拆解
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4. 证据与数字
Design: Baseline, and 2-, 4-, and 6-year follow-up brain imaging and BMI from the Adolescent Brain Cognitive DevelopmentSM Study, analyzed between June 2025 and June 2026.
Setting: Multicenter, population-based study including 21 sites distributed across the US.
Participants: 10,479 adolescents (5,078 [48.5%] female; aged 9-18 years) from this population-based cohort study were included after quality control of complete data.
5. 反例与边界
Results: A total of 10,479 participants (5,078 [48.5%] female; aged 9-18 years) contributed 22,049 imaging obs
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