Function-driven geometry directs human pilosebaceous unit development
Farr, E.; Kritikaki, E.; Chroscik, M.; Admane, C.; Graves, E.; Tudor, C.; Chan, H. M.; Boccacino, J.; McWilliam, J.; Torabi, F.; Chakala, K.; Basurto-Lozada, D.; Li, T.; Binkevich, A.; Predeus, A.; Pr · developmental biology · 2026-09-04 · 原文
DOI：10.64898/2026.08.31.745265作者：16 位
Single-cell technologies have generated cell censuses of tissues, however, how tissue geometry reflects functional needs remains poorly characterized. The human pilosebaceous unit offers a tractable model, a prenatally-formed complex mini-organ combining hair and sebum production with a stem cell reservoir. Using histomorphology, spatial transcriptomics, and single-cell multiomics on the same human prenatal scalp skin samples (8-19 post-conception weeks), integrated and analyzed using machine learning approaches, we built a spatiotemporal map of pilosebaceous unit development. We demonstrate that epithelial-mesenchymal interactions coordinate cellular fate and organogenesis, using an in vitro hair-bearing skin organoid model to validate this tissue-patterning. In addition, we show sebaceous gland developmental programmes are overcome during tumor formation. Our large-scale multi-modal analysis provides a unique framework for understanding form and function of tissues with applications in tissue engineering and pathology.
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1. 人话版
Single-cell technologies have generated cell censuses of tissues, however, how tissue geometry reflects functional needs remains poorly characterized.
The human pilosebaceous unit offers a tractable model, a prenatally-formed complex mini-organ combining hair and sebum production with a stem cell reservoir.
2. 领域脉络
本文类目：developmental biology，属于其所在研究脉络的最新进展。
3. 机制拆解
We demonstrate that epithelial-mesenchymal interactions coordinate cellular fate and organogenesis, using an in vitro hair-bearing skin organoid model to validate this tissue-patterning.
In addition, we show sebaceous gland developmental programmes are overcome during tumor formation.
4. 证据与数字
Using histomorphology, spatial transcriptomics, and single-cell multiomics on the same human prenatal scalp skin samples (8-19 post-conception weeks), integrated and analyzed using machine learning approaches, we built a spatiotemporal map of pilosebaceous unit development.
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