A Multi-Omics Study of Cognitive Resilience to Alzheimer's Disease
Wang, E.; Xie, B.; Wang, M.; Fu, Y.; Wang, X.; Li, Y.; Xu, P.; Liu, H.; Ho, L.; Tu, Z.; Mobbs, C.; Gaiteri, C.; Ehrlich, M. E.; Bennett, D. A.; Haroutunian, V.; Peng, J.; Zhang, B. · genomics · 2026-09-06 · 原文
DOI：10.64898/2026.09.02.746746作者：17 位
Alzheimers disease (AD) is the most severe form of dementia. While significant efforts have been made to identify AD risk factors and develop therapeutics, much less attention has been given to neurobiological factors and molecular signatures associated with cognitive resilience. Substantial evidence suggests that modifiable factors, such as physical and mental activity, may contribute to cognitive reserve and resilience. To this end, we developed a resilient cohort of paired genetics, transcriptomics and proteomics data from the prefrontal cortex of 282 cognitively normal older adults. We conducted extensive preprocessing and rigorous quality control (QC), including QC on sequence metrics and sample matching across multiomics. This cohort can be leveraged for identification of molecular signatures of cognitive resilience to AD and is freely shared with the research community.
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1. 人话版
Alzheimers disease (AD) is the most severe form of dementia.
While significant efforts have been made to identify AD risk factors and develop therapeutics, much less attention has been given to neurobiological factors and molecular signatures associated with cognitive resilience.
2. 领域脉络
本文类目：genomics，属于其所在研究脉络的最新进展。
3. 机制拆解
We conducted extensive preprocessing and rigorous quality control (QC), including QC on sequence metrics and sample matching across multiomics.
4. 证据与数字
To this end, we developed a resilient cohort of paired genetics, transcriptomics and proteomics data from the prefrontal cortex of 282 cognitively normal older adults.
5. 反例与边界
Substantial evidence suggests that modifiable factors, such as physical and mental activity, may contribute to cognitive reserve and resilience.
6. 跨领域连接与意外收获
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7. 可复用方法
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8. 术语表
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