Selectively Advantageous Instability and Information Theory in Sex-specific Aging
Tower, J. · systems biology · 2026-09-07 · 原文
DOI：10.64898/2026.09.02.748817
Biological information is generally thought to be subject to selection for faithful maintenance. However, accurate preservation is often combined with regulated mechanisms that generate state change. Selectively advantageous instability (SAI) is modeled here as instability that is favored because useful alternatives become accessible. In a minimal AB replicator, degradation of B destroys a functional AB complex but releases A, which permits formation of the superior AAB replicator. Positive selected instability therefore expands the occupied state distribution and necessarily increases Shannon state entropy relative to the corresponding perfectly stable system. Modeling shows that active destabilization is favored above a threshold determined by environmental change, passive error, destabilization cost, and the relative adaptive targeting of active versus passive variation. Importantly, when actively generated variation is sufficiently structured, selection simultaneously favors increased maintenance and increased active destabilization of the same information channel. This relationship is described as stabilization-destabilization complementarity. Shannon entropy quantifies uncert
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1. 人话版
Biological information is generally thought to be subject to selection for faithful maintenance.
However, accurate preservation is often combined with regulated mechanisms that generate state change.
2. 领域脉络
本文类目：systems biology，属于其所在研究脉络的最新进展。
3. 机制拆解
Selectively advantageous instability (SAI) is modeled here as instability that is favored because useful alternatives become accessible.
4. 证据与数字
摘要未给出量化结果——留意原文的实验与数据。
5. 反例与边界
In a minimal AB replicator, degradation of B destroys a functional AB complex but releases A, which permits formation of the superior AAB replicator.
Positive selected instability therefore expands the occupied state distribution and necessarily increases Shannon state entropy relative to the corresponding perfectly stable system.
6. 跨领域连接与意外收获
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7. 可复用方法
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8. 术语表
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