Sexual dimorphism of autism-like phenotypes in microglial eIF4E overexpression mice
Niu, C.; An, J. J.; Masterson, H. V.; Xu, B. · genetics · 2026-09-07 · 原文
DOI：10.64898/2026.09.03.748596作者：4 位
Background: Autism spectrum disorder (ASD) is a group of neurodevelopmental disorders characterized by deficits in social communication and interaction, and restricted interests or repetitive behaviors. ASD is approximately four times more prevalent in males than in females. In this study, we investigated whether sex hormones or sex chromosomes underlie the male bias in ASD susceptibility. Methods: We used the MG4E mouse model, in which microglial eIF4E overexpression produces robust male-biased ASD-like phenotypes. To distinguish the contributions of sex hormones and sex chromosomes, MG4E mice were crossed with four-core-genotype (FCG) mice carrying Sry gene manipulations, generating eight genotypes of experimental mice. Social interaction and repetitive behaviors were assessed using standard behavioral assays. Dendritic spine density was quantified in Thy1-GFP mice. Expression of estrogen receptors (ERs) and androgen receptor (AR) was examined in microglia isolated from control and MG4E mice. Results: Sex hormones, rather than non-Sry genes on sex chromosomes, are responsible for the male-biased deficits in social interaction and the increase in dendritic spine density. At postna
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1. 人话版
Background: Autism spectrum disorder (ASD) is a group of neurodevelopmental disorders characterized by deficits in social communication and interaction, and restricted interests or repetitive behaviors.
ASD is approximately four times more prevalent in males than in females.
2. 领域脉络
本文类目：genetics，属于其所在研究脉络的最新进展。
3. 机制拆解
In this study, we investigated whether sex hormones or sex chromosomes underlie the male bias in ASD susceptibility.
4. 证据与数字
Methods: We used the MG4E mouse model, in which microglial eIF4E overexpression produces robust male-biased ASD-like phenotypes.
To distinguish the contributions of sex hormones and sex chromosomes, MG4E mice were crossed with four-core-genotype (FCG) mice carrying Sry gene manipulations, generating eight genotypes of experimental mice.
Dendritic spine density was quantified in Thy1-GFP mice.
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