Cohort-Defined Low Skeletal Muscle Mass and Functional Dependency After Critical Illness: A 12-Month Longitudinal Study
· 2026-09-10 · 原文
DOI：10.64898/2026.09.04.26362259v1?rss=1
Objective: To evaluate the association between low skeletal muscle mass at intensive care unit (ICU) enrollment and functional dependency at 1, 3, 6, and 12 months after enrollment. Design: Prospective longitudinal observational cohort with follow-up at 1, 3, 6, and 12 months after enrollment. Exposure: Sex-defined low muscle mass (LMM), using L3 skeletal muscle index (SMI) thresholds of <33.2 cm2/m2 in men and <28.3 cm2/m2 in women, derived from the cohort distribution. Main outcome and analysis: Need for assistance with activities of daily living, transfers, or toileting. Logistic generalized estimating equations (GEE) included LMM-by-time interactions, adjustment for sepsis, sex, and age <65 years, and mortality-derived inverse probability weights. Results: Among 217 participants, 148 h
讲义
讲义·推断 依据「原文」自动生成的结构化摘要（推断），非原文表述；以原文为准。
1. 人话版
Objective: To evaluate the association between low skeletal muscle mass at intensive care unit (ICU) enrollment and functional dependency at 1, 3, 6, and 12 months after enrollment.
Design: Prospective longitudinal observational cohort with follow-up at 1, 3, 6, and 12 months after enrollment.
2. 领域脉络
来源板块：板块一 · 研究前沿。
3. 机制拆解
Main outcome and analysis: Need for assistance with activities of daily living, transfers, or toileting.
4. 证据与数字
Exposure: Sex-defined low muscle mass (LMM), using L3 skeletal muscle index (SMI) thresholds of <33.2 cm2/m2 in men and <28.3 cm2/m2 in women, derived from the cohort distribution.
Logistic generalized estimating equations (GEE) included LMM-by-time interactions, adjustment for sepsis, sex, and age <65 years, and mortality-derived inverse probability weights.
Results: Among 217 participants, 148 h
5. 反例与边界
摘要未声明局限与反例——这是需要警惕的信号，精读时先问边界。
6. 跨领域连接与意外收获
思考本文机制能否迁移到你正在跟进的问题。
7. 可复用方法
把本文机制与你手头项目对照，找一个两周内能验证的最小实验。
8. 术语表
精读时把不熟的术语记入此处，作为下次回忆的锚点。