The distribution of fitness effects of nonsynonymous mutations varies phylogenetically across animals
· 2026-09-08 · 原文
DOI：10.1371/journal.pbio.3003976
by Meixi Lin, Sneha Chakraborty, Carlos Eduardo G. Amorim, Sergio F. Nigenda-Morales, Annabel C. Beichman, Paulina G. Nuñez-Valencia, Jonathan C. Mah, Jacqueline A. Robinson, Christopher C. Kyriazis, Christian D. Huber, Andrew E. Webb, Sarah D. Kocher, Frederick I. Archer, Andrés Moreno-Estrada, Robert K. Wayne, Kirk E. Lohmueller The distribution of fitness effects (DFE) describes the selection coefficients of newly arising mutations and fundamentally influences population genetic processes. However, the extent and mechanisms of differences in the DFE for non-synonymous mutations have not been systematically investigated across species with divergent phylogenetic histories and ecologies. Here, we inferred the DFE in natural populations of 11 animal (sub)species, including humans, mice, fi
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1. 人话版
by Meixi Lin, Sneha Chakraborty, Carlos Eduardo G.
Amorim, Sergio F.
2. 领域脉络
Nigenda-Morales, Annabel C.
3. 机制拆解
Beichman, Paulina G.
Nuñez-Valencia, Jonathan C.
4. 证据与数字
Here, we inferred the DFE in natural populations of 11 animal (sub)species, including humans, mice, fi
5. 反例与边界
Lohmueller The distribution of fitness effects (DFE) describes the selection coefficients of newly arising mutations and fundamentally influences population genetic processes.
However, the extent and mechanisms of differences in the DFE for non-synonymous mutations have not been systematically investigated across species with divergent phylogenetic histories and ecologies.
6. 跨领域连接与意外收获
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7. 可复用方法
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8. 术语表
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