Functional gut microbiome dysbiosis is associated with overall survival after solid organ transplantation
· 2026-09-09 · 原文
DOI：10.64898/2026.09.04.26362223v1?rss=1
Background Long-term survival after solid organ transplantation remains limited by infection, graft dysfunction, and systemic complications. Recent evidence suggests that gut dysbiosis, marked by loss of beneficial commensals and expansion of opportunistic pathogens, is associated with increased mortality in solid organ transplant recipients (SOTRs). While specific species have been associated with higher mortality risk or improved survival, the functional mechanisms on the strain level underlying these associations remain unclear. Here, we integrated gene-centric functional profiling with strain-level resolved metagenome-assembled genomes (MAGs) across 1231 gut metagenomes from 1008 SOTRs (580 kidney, 245 liver, 133 lung and 50 heart transplant recipients) and 233 healthy controls from th
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1. 人话版
Background Long-term survival after solid organ transplantation remains limited by infection, graft dysfunction, and systemic complications.
Recent evidence suggests that gut dysbiosis, marked by loss of beneficial commensals and expansion of opportunistic pathogens, is associated with increased mortality in solid organ transplant recipients (SOTRs).
2. 领域脉络
While specific species have been associated with higher mortality risk or improved survival, the functional mechanisms on the strain level underlying these associations remain unclear.
3. 机制拆解
摘要未展开方法细节——精读时重点看方法/模型部分。
4. 证据与数字
Here, we integrated gene-centric functional profiling with strain-level resolved metagenome-assembled genomes (MAGs) across 1231 gut metagenomes from 1008 SOTRs (580 kidney, 245 liver, 133 lung and 50 heart transplant recipients) and 233 healthy controls from th
5. 反例与边界
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6. 跨领域连接与意外收获
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7. 可复用方法
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8. 术语表
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