The carbohydrate utilization regulator Cbr1 coordinates nutrient-specific gene activation with selective carbon catabolite repression in a basidiomycete yeast
· 2026-09-01 · 原文
DOI：10.1371/journal.pbio.3003983
by Brandon Reyes-Chavez, Joshua D. Kerkaert, Lori B. Huberman Cells must sense and respond to nutrients to survive. To efficiently grow in mixed carbon environments, microbes repress genes necessary to utilize carbon sources that require substantial resources to catabolize when a simpler carbon source, such as glucose, is present. This process is known as carbon catabolite repression. Canonically, in fungi, nutrient sensing transcriptional networks are composed of carbon source-specific transcription factors that activate carbon source utilization genes and carbon catabolite repression regulators, which broadly repress all nonpreferred carbon source utilization genes when a preferred carbohydrate is present. In contrast to this model, we identified a transcription factor (Cbr1) in the basi
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1. 人话版
by Brandon Reyes-Chavez, Joshua D.
Kerkaert, Lori B.
2. 领域脉络
Huberman Cells must sense and respond to nutrients to survive.
3. 机制拆解
To efficiently grow in mixed carbon environments, microbes repress genes necessary to utilize carbon sources that require substantial resources to catabolize when a simpler carbon source, such as glucose, is present.
This process is known as carbon catabolite repression.
4. 证据与数字
In contrast to this model, we identified a transcription factor (Cbr1) in the basi
5. 反例与边界
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6. 跨领域连接与意外收获
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7. 可复用方法
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8. 术语表
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