Distinct sensorimotor encoding in tuft dendrites and somata associated with action, correction, and learning
· 2026-09-02 · 原文
Frontal cortex plays critical roles in action control and motor skill learning. Within the layer 1 apical tuft dendrites of layer 5 (L5) neurons in the frontal cortex, precise input patterns and back-propagating action potentials can trigger powerful regenerative events that may be essential for flexible computation and learning. However, it remains unclear whether tuft activity in frontal cortical L5 circuits encodes sensorimotor information that differs from the information conveyed by their outputs to downstream targets. Using longitudinal two-photon calcium imaging, we investigated sensorimotor encoding in the apical tuft dendrites and somata of L5 extratelencephalic neurons in the frontal cortex of mice during learning of a discrete change to a cued dexterous action. During learning,
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1. 人话版
Frontal cortex plays critical roles in action control and motor skill learning.
Within the layer 1 apical tuft dendrites of layer 5 (L5) neurons in the frontal cortex, precise input patterns and back-propagating action potentials can trigger powerful regenerative events that may be essential for flexible computation and learning.
2. 领域脉络
来源板块：板块二 · 顶级期刊。
3. 机制拆解
During learning,
4. 证据与数字
However, it remains unclear whether tuft activity in frontal cortical L5 circuits encodes sensorimotor information that differs from the information conveyed by their outputs to downstream targets.
Using longitudinal two-photon calcium imaging, we investigated sensorimotor encoding in the apical tuft dendrites and somata of L5 extratelencephalic neurons in the frontal cortex of mice during learning of a discrete change to a cued dexterous action.
5. 反例与边界
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6. 跨领域连接与意外收获
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7. 可复用方法
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8. 术语表
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