A kidney-conditioned urinary peptidomic biological ageing clock predicts all-cause mortality and age-related health outcomes
· 2026-09-04 · 原文
DOI：10.64898/2026.09.01.26361640v1?rss=1预印本：medRxiv开放获取：绿色OA
Background Ageing clocks are promising non-invasive tools to assess biological ageing, but they generally cannot guide intervention. We aimed to develop a urinary peptidomic ageing clock, expected to react to intervention, and to test whether the resulting age acceleration predicts all-cause mortality and adverse health outcomes. Methods In this retrospective multi-cohort study, urinary peptides were measured by capillary electrophoresis-mass spectrometry (CE-MS). An unconditioned clock (UPBioAge) was developed in a kidney function-preserved derivation cohort (n = 1,811), then conditioned on estimated glomerular filtration rate (eGFR) and urinary albumin-to-creatinine ratio (UACR) by Filtrate-Aware Calibration (FAC) fitted in an independent kidney-diverse cohort (n = 7,798), resulting in k
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1. 人话版
Background Ageing clocks are promising non-invasive tools to assess biological ageing, but they generally cannot guide intervention.
We aimed to develop a urinary peptidomic ageing clock, expected to react to intervention, and to test whether the resulting age acceleration predicts all-cause mortality and adverse health outcomes.
2. 领域脉络
Methods In this retrospective multi-cohort study, urinary peptides were measured by capillary electrophoresis-mass spectrometry (CE-MS).
3. 机制拆解
摘要未展开方法细节——精读时重点看方法/模型部分。
4. 证据与数字
An unconditioned clock (UPBioAge) was developed in a kidney function-preserved derivation cohort (n = 1,811), then conditioned on estimated glomerular filtration rate (eGFR) and urinary albumin-to-creatinine ratio (UACR) by Filtrate-Aware Calibration (FAC) fitted in an independent kidney-diverse cohort (n = 7,798), resulting in k
5. 反例与边界
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6. 跨领域连接与意外收获
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7. 可复用方法
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8. 术语表
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