Genetic and behavioural architecture of childhood eating behaviour and links to obesity risk
· 2026-09-04 · 原文
DOI：10.64898/2026.09.02.26362007v1?rss=1预印本：medRxiv开放获取：绿色OA
Background/Objectives: Childhood appetitive traits are heritable behavioural phenotypes hypothesized to link genetic susceptibility to obesity risk. Yet their genetic architecture and role in mediating polygenic adiposity risk remain poorly understood. Methods: We conducted the largest survey of childhood eating behaviour to date, allowing us to perform genome-wide association studies of six appetitive domains derived from 18 items of the parent-reported Children's Eating Behaviour Questionnaire in up to 31,018 eight-year-old children from the Norwegian Mother, Father and Child Cohort Study (MoBa). A trio-based design enabled decomposition of direct and indirect genetic effects on appetite and BMI. Results: We identified ten independent genome-wide significant loci for childhood eating beh
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1. 人话版
Background/Objectives: Childhood appetitive traits are heritable behavioural phenotypes hypothesized to link genetic susceptibility to obesity risk.
Yet their genetic architecture and role in mediating polygenic adiposity risk remain poorly understood.
2. 领域脉络
来源板块：板块一 · 研究前沿。
3. 机制拆解
A trio-based design enabled decomposition of direct and indirect genetic effects on appetite and BMI.
Results: We identified ten independent genome-wide significant loci for childhood eating beh
4. 证据与数字
Methods: We conducted the largest survey of childhood eating behaviour to date, allowing us to perform genome-wide association studies of six appetitive domains derived from 18 items of the parent-reported Children's Eating Behaviour Questionnaire in up to 31,018 eight-year-old children from the Norwegian Mother, Father and Child Cohort Study (MoBa).
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6. 跨领域连接与意外收获
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7. 可复用方法
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8. 术语表
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