The insulin/IGF axis is critically important for controlling gene transcription in the podocyte
· 2026-09-04 · 原文
Podocyte integrity depends critically on signalling through the insulin receptor and IGF1 receptor , and this study defines their combined importance using dual-receptor knockdown in mice and cultured podocytes. Podocyte-specific reduction of both receptors in transgenic mice caused kidney disease characterised by albuminuria and glomerulosclerosis, with premature death occurring in some animals between 4 and 24 weeks. Receptor-deficient cultured podocytes exhibited >50% cell loss within 7 days. Integrated proteomic and transcriptomic analyses revealed marked depletion of spliceosome-associated proteins and widespread intron retention with premature termination codons, indicating profound disruption of RNA processing. Phospho-proteomic profiling further showed that insulin/IGF1 stimulat
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1. 人话版
Podocyte integrity depends critically on signalling through the insulin receptor and IGF1 receptor , and this study defines their combined importance using dual-receptor knockdown in mice and cultured podocytes.
Podocyte-specific reduction of both receptors in transgenic mice caused kidney disease characterised by albuminuria and glomerulosclerosis, with premature death occurring in some animals between 4 and 24 weeks.
2. 领域脉络
来源板块：板块二 · 顶级期刊。
3. 机制拆解
Integrated proteomic and transcriptomic analyses revealed marked depletion of spliceosome-associated proteins and widespread intron retention with premature termination codons, indicating profound disruption of RNA processing.
4. 证据与数字
Receptor-deficient cultured podocytes exhibited >50% cell loss within 7 days.
Phospho-proteomic profiling further showed that insulin/IGF1 stimulat
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6. 跨领域连接与意外收获
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8. 术语表
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