Red blood cell distribution width is an indicator of physiological dysregulation and reveals the relationship between biomarkers and health status in hemodialysis patients
· 2026-09-08 · 原文
DOI：10.64898/2026.09.04.26362306v1?rss=1
Introduction: Red blood cell distribution width (RDW) and intra-individual variability (IIV) of biomarkers are different types of variation. Although their high levels are commonly associated with high mortality risks and poor clinical outcomes, the reason for this remains unclear. Methods: We explored the significance of this similarity using time-series data (from 143,475 samples) collected over a 9-year period from 1,216 patients on long-term hemodialysis. The IIV of each of the 22 blood-based biomarkers was assessed using the moving coefficient of variation (mCV). Non-linear longitudinal/temporal changes of the variables and their mutual relationships were analyzed using generalized additive (mixed) models. Results: RDW and all of the IIVs showed similar trends throughout the entire pe
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1. 人话版
Introduction: Red blood cell distribution width (RDW) and intra-individual variability (IIV) of biomarkers are different types of variation.
Although their high levels are commonly associated with high mortality risks and poor clinical outcomes, the reason for this remains unclear.
2. 领域脉络
来源板块：板块一 · 研究前沿。
3. 机制拆解
Non-linear longitudinal/temporal changes of the variables and their mutual relationships were analyzed using generalized additive (mixed) models.
4. 证据与数字
Methods: We explored the significance of this similarity using time-series data (from 143,475 samples) collected over a 9-year period from 1,216 patients on long-term hemodialysis.
The IIV of each of the 22 blood-based biomarkers was assessed using the moving coefficient of variation (mCV).
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6. 跨领域连接与意外收获
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