Connecting diet and disease: Using Mendelian randomisation to bridge the gap
· 2026-09-04 · 原文
DOI：10.64898/2026.09.02.26362020v1?rss=1预印本：medRxiv开放获取：绿色OA
Establishing causality in nutrition research is challenging. While randomised controlled trials (RCTs) provide robust evidence, long-term dietary intervention studies with disease endpoints are often impractical. Short-term RCTs can instead identify intermediate traits that may lie on the causal pathway between diet and disease. Mendelian randomisation (MR) is an epidemiological approach that uses genetic variants as proxies for modifiable exposures to estimate the effects of lifelong differences in exposure on disease risk. However, the utility of MR is limited for complex dietary patterns because genetic variants typically reflect biological mechanisms rather than specific diets. We propose a two-step framework integrating dietary RCTs with MR to infer potential lifetime effects of dieta
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1. 人话版
Establishing causality in nutrition research is challenging.
While randomised controlled trials (RCTs) provide robust evidence, long-term dietary intervention studies with disease endpoints are often impractical.
2. 领域脉络
Short-term RCTs can instead identify intermediate traits that may lie on the causal pathway between diet and disease.
3. 机制拆解
Mendelian randomisation (MR) is an epidemiological approach that uses genetic variants as proxies for modifiable exposures to estimate the effects of lifelong differences in exposure on disease risk.
4. 证据与数字
摘要未给出量化结果——留意原文的实验与数据。
5. 反例与边界
However, the utility of MR is limited for complex dietary patterns because genetic variants typically reflect biological mechanisms rather than specific diets.
6. 跨领域连接与意外收获
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7. 可复用方法
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8. 术语表
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