Risk of acute gastroenteritis following COVID-19 exposure: a retrospective population-based analysis conducted in England
· 2026-09-09 · 原文
DOI：10.64898/2026.09.07.26362439v1?rss=1
Background Severe COVID-19 is associated with immune dysregulation, microbiome disruption, and increased vulnerability to secondary infections. However, the longer-term risk of acute gastroenteritis (AGE) following COVID-19 remains poorly studied. We compared AGE incidence among community-managed and hospitalised COVID-19 patients with test-negative controls and hospitalised sepsis patients. Methods We conducted a retrospective cohort study using electronic healthcare data. Patients with a recorded SARS-CoV-2 PCR test between 01 March 2020 and 01 March 2022 were allocated to test-negative, community COVID-19, or hospitalised COVID-19 cohorts. A hospitalised sepsis cohort was assembled for an age-, sex- and time-matched analysis. AGE incidence rates were calculated for the two years before
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1. 人话版
Background Severe COVID-19 is associated with immune dysregulation, microbiome disruption, and increased vulnerability to secondary infections.
However, the longer-term risk of acute gastroenteritis (AGE) following COVID-19 remains poorly studied.
2. 领域脉络
来源板块：板块一 · 研究前沿。
3. 机制拆解
Methods We conducted a retrospective cohort study using electronic healthcare data.
4. 证据与数字
We compared AGE incidence among community-managed and hospitalised COVID-19 patients with test-negative controls and hospitalised sepsis patients.
Patients with a recorded SARS-CoV-2 PCR test between 01 March 2020 and 01 March 2022 were allocated to test-negative, community COVID-19, or hospitalised COVID-19 cohorts.
5. 反例与边界
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6. 跨领域连接与意外收获
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7. 可复用方法
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8. 术语表
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