Association between Plasmodium falciparum Kelch13 mutations and malaria parasite clearance half-life after artemisinin-based therapy: an updated WWARN systematic review and individual patient data meta-analysis
· 2026-09-10 · 原文
DOI：10.64898/2026.09.08.26362414v1?rss=1
Background: Artemisinin-based combination therapies remain the first-line treatment for uncomplicated Plasmodium falciparum malaria. Plasmodium falciparum Kelch13 mutations emerge and spread within distinct malaria epidemiological and immunological contexts, shaping the expression of artemisinin resistance (ART-R). Understanding the clinical phenotypes of these mutations requires evaluation across diverse transmission settings and geographic regions. Methods: A systematic review (SR) and individual patient data meta-analysis (IPDMA) were conducted (PROSPERO: CRD42019133366) to identify studies that included serial parasite density measurements and Kelch13 genotyping. Associations between Kelch13 mutations and parasite clearance half-lives (PC1/2) and Day 3 parasite positivity were assessed
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1. 人话版
Background: Artemisinin-based combination therapies remain the first-line treatment for uncomplicated Plasmodium falciparum malaria.
Plasmodium falciparum Kelch13 mutations emerge and spread within distinct malaria epidemiological and immunological contexts, shaping the expression of artemisinin resistance (ART-R).
2. 领域脉络
Understanding the clinical phenotypes of these mutations requires evaluation across diverse transmission settings and geographic regions.
3. 机制拆解
摘要未展开方法细节——精读时重点看方法/模型部分。
4. 证据与数字
Methods: A systematic review (SR) and individual patient data meta-analysis (IPDMA) were conducted (PROSPERO: CRD42019133366) to identify studies that included serial parasite density measurements and Kelch13 genotyping.
Associations between Kelch13 mutations and parasite clearance half-lives (PC1/2) and Day 3 parasite positivity were assessed
5. 反例与边界
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6. 跨领域连接与意外收获
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7. 可复用方法
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8. 术语表
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