Testing Claimed Associations of Prenatal Acetaminophen with Neurodevelopmental Disorders: Re-analysis Using Bias-Correction Methods

· 2026-09-04 · 原文

DOI：10.64898/2026.08.28.26361666v1?rss=1

Background: A 2025 systematic review concluded there was "strong evidence of a likely relationship" between prenatal acetaminophen exposure and neurodevelopmental disorders, informing a federal health advisory, based on qualitative synthesis without quantitative pooling or bias correction. We reanalysed the same studies to test whether this association withstands standard meta-analytic and bias-correction methods. Methods: We used 24 of 46 studies from a 2025 Navigation Guide systematic review (PubMed search through 25 February 2025) that reported a ratio measure (hazard ratio, odds ratio, relative risk, or incidence rate ratio). Estimates were collapsed to one per study, outcome group, and design, yielding 30 study-level estimates (sample sizes, 307-2,480,797) for attention-deficit/hypera

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1. 人话版

We reanalysed the same studies to test whether this association withstands standard meta-analytic and bias-correction methods.

2. 领域脉络

来源板块：板块一 · 研究前沿。

3. 机制拆解

摘要未展开方法细节——精读时重点看方法/模型部分。

4. 证据与数字

Methods: We used 24 of 46 studies from a 2025 Navigation Guide systematic review (PubMed search through 25 February 2025) that reported a ratio measure (hazard ratio, odds ratio, relative risk, or incidence rate ratio).

Estimates were collapsed to one per study, outcome group, and design, yielding 30 study-level estimates (sample sizes, 307-2,480,797) for attention-deficit/hypera

5. 反例与边界

摘要未声明局限与反例——这是需要警惕的信号，精读时先问边界。

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