Clinical Phenotypes of Post-Acute Sequelae of SARS-CoV-2 (PASC) Infection: A Longitudinal Cohort Study from Karachi, Pakistan
· 2026-09-08 · 原文
DOI：10.64898/2026.09.04.26361413v1?rss=1
Post Acute Sequelae of SARS CoV 2 infection, or PASC, is an emerging public health concern. Longitudinal data from South Asia remain limited and the burden of persistent symptoms in Pakistan is not well characterized. This study examined the long term clinical course of PASC and its relationship with fecal viral shedding and serotonin levels over a 12 month follow up period. We conducted a prospective longitudinal study of individuals with PASC. Participants underwent serial assessments of clinical symptoms, stool SARS CoV 2 RNA detection, and serum serotonin measurements. A symptom score was developed using 22 symptoms reported by more than 30 percent of participants. Participants were predominantly female with 60 percent female participation and a mean age of 42.1 years. Overall, 66 perc
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1. 人话版
Post Acute Sequelae of SARS CoV 2 infection, or PASC, is an emerging public health concern.
Longitudinal data from South Asia remain limited and the burden of persistent symptoms in Pakistan is not well characterized.
2. 领域脉络
来源板块：板块一 · 研究前沿。
3. 机制拆解
We conducted a prospective longitudinal study of individuals with PASC.
4. 证据与数字
This study examined the long term clinical course of PASC and its relationship with fecal viral shedding and serotonin levels over a 12 month follow up period.
Participants underwent serial assessments of clinical symptoms, stool SARS CoV 2 RNA detection, and serum serotonin measurements.
A symptom score was developed using 22 symptoms reported by more than 30 percent of participants.
5. 反例与边界
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6. 跨领域连接与意外收获
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7. 可复用方法
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8. 术语表
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