Impaired midfrontal‑motor theta phase synchronization characterizes maladaptive motivational behavior in people with obsessive‑compulsive disorder
· 2026-09-01 · 原文
DOI：10.1371/journal.pbio.3003979
by Yu Pang, Dongsheng Zhou, Ziwen Peng, Wanting Liu, Ruojie Huang, Carol A. Seger, Qi Chen Obsessive‑compulsive disorder (OCD) is characterized by an insight‑action dissociation, in which people with OCD recognize that their behavior is irrational but still struggle to inhibit habitual responses. This dissociation may be related to abnormally strong motivational biases, reflected in excessive tendencies to approach reward and avoid punishment. We employed a motivational Go/NoGo learning task, combined with computational modeling and electroencephalography (EEG), to investigate how 36 people with OCD and 37 healthy controls (HC) regulate maladaptive biases during motivated action. People with OCD showed stronger Pavlovian bias and lower learning rates. Similar to HC, people with OCD also sh
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1. 人话版
by Yu Pang, Dongsheng Zhou, Ziwen Peng, Wanting Liu, Ruojie Huang, Carol A.
Seger, Qi Chen Obsessive‑compulsive disorder (OCD) is characterized by an insight‑action dissociation, in which people with OCD recognize that their behavior is irrational but still struggle to inhibit habitual responses.
2. 领域脉络
This dissociation may be related to abnormally strong motivational biases, reflected in excessive tendencies to approach reward and avoid punishment.
3. 机制拆解
People with OCD showed stronger Pavlovian bias and lower learning rates.
4. 证据与数字
We employed a motivational Go/NoGo learning task, combined with computational modeling and electroencephalography (EEG), to investigate how 36 people with OCD and 37 healthy controls (HC) regulate maladaptive biases during motivated action.
5. 反例与边界
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6. 跨领域连接与意外收获
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7. 可复用方法
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8. 术语表
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