Genetic liability to ADHD and migraine risk: Mendelian randomization evidence for behavioural and psychiatric pathways
· 2026-09-10 · 原文
DOI：10.64898/2026.09.08.26362527v1?rss=1
Background: Attention-deficit/hyperactivity disorder (ADHD) and migraine frequently co-occur, but the mechanisms underlying this association remain unclear. Examining migraine with aura and without aura separately may help clarify whether ADHD-related pathways are shared across migraine subtypes or differ by aura status. Methods: Two-sample Mendelian randomization (MR) was used to examine the effect of genetic liability to ADHD on overall migraine and on migraine subtypes defined by aura status. MR-based mediation was then used to assess whether behavioural, psychiatric, sleep-related, education, and cardiometabolic traits contribute to these effects. Results: MR provided evidence for an effect of ADHD genetic liability on overall migraine risk (OR = 1.48, 95% CI =1.2, 1.82), with similar
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1. 人话版
Background: Attention-deficit/hyperactivity disorder (ADHD) and migraine frequently co-occur, but the mechanisms underlying this association remain unclear.
Examining migraine with aura and without aura separately may help clarify whether ADHD-related pathways are shared across migraine subtypes or differ by aura status.
2. 领域脉络
Methods: Two-sample Mendelian randomization (MR) was used to examine the effect of genetic liability to ADHD on overall migraine and on migraine subtypes defined by aura status.
3. 机制拆解
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4. 证据与数字
Results: MR provided evidence for an effect of ADHD genetic liability on overall migraine risk (OR = 1.48, 95% CI =1.2, 1.82), with similar
5. 反例与边界
MR-based mediation was then used to assess whether behavioural, psychiatric, sleep-related, education, and cardiometabolic traits contribute to these effects.
6. 跨领域连接与意外收获
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7. 可复用方法
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