REM sleep prefrontal high-frequency oscillation chains mediate distinct cortical – hippocampal reactivation patterns compared to NREM sleep
· 2026-09-07 · 原文
REM (rapid eye movement) and non-REM (NREM) sleep stages contribute to systems memory consolidation in hippocampal–cortical circuits. However, the physiological mechanisms underlying REM memory processes remain relatively unclear compared to NREM memory reactivation. Here we report, in rodents, the existence of prefrontal cortical (PFC) high-frequency oscillation (HFO) chains in REM sleep during the consolidation of recently acquired spatial memory. High-density tetrode recordings in hippocampal area CA1 and PFC reveal that REM cortical HFOs occur in characteristic chains that are phase-modulated by theta oscillations, corresponding to increased CA1-PFC theta coherence and delineating periods of enhanced hippocampal–cortical communication. REM HFO chains sequentially organize sparse PFC en
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1. 人话版
REM (rapid eye movement) and non-REM (NREM) sleep stages contribute to systems memory consolidation in hippocampal–cortical circuits.
However, the physiological mechanisms underlying REM memory processes remain relatively unclear compared to NREM memory reactivation.
2. 领域脉络
Here we report, in rodents, the existence of prefrontal cortical (PFC) high-frequency oscillation (HFO) chains in REM sleep during the consolidation of recently acquired spatial memory.
3. 机制拆解
REM HFO chains sequentially organize sparse PFC en
4. 证据与数字
High-density tetrode recordings in hippocampal area CA1 and PFC reveal that REM cortical HFOs occur in characteristic chains that are phase-modulated by theta oscillations, corresponding to increased CA1-PFC theta coherence and delineating periods of enhanced hippocampal–cortical communication.
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6. 跨领域连接与意外收获
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