Trpv4 links environmental temperature to testicular differentiation in hermaphroditic ricefield eel
· 2026-09-07 · 原文
The ricefield eel ( Monopterus albus ), an economically important aquaculture species in China, is a freshwater teleost fish that exhibits protogynous hermaphroditism. Although progress has been made in understanding the sex determination and differentiation of this species, the underlying mechanisms remain unclear. Here, we show that warm temperature promotes gonadal transformation by up-regulating testicular differentiation genes, such as dmrt1 / sox9a in ovaries. Trpv4, a Ca 2+ -permeable cation channel expressed in gonadal somatic cells, is highly sensitive to ambient temperature and links environmental temperature to testicular differentiation in ricefield eel. In female fish reared at cool temperature, injection of Trpv4 agonist into the ovaries leads to a significant upregulation of
讲义
讲义·推断 依据「原文」自动生成的结构化摘要（推断），非原文表述；以原文为准。
1. 人话版
The ricefield eel ( Monopterus albus ), an economically important aquaculture species in China, is a freshwater teleost fish that exhibits protogynous hermaphroditism.
Although progress has been made in understanding the sex determination and differentiation of this species, the underlying mechanisms remain unclear.
2. 领域脉络
来源板块：板块二 · 顶级期刊。
3. 机制拆解
摘要未展开方法细节——精读时重点看方法/模型部分。
4. 证据与数字
Here, we show that warm temperature promotes gonadal transformation by up-regulating testicular differentiation genes, such as dmrt1 / sox9a in ovaries.
Trpv4, a Ca 2+ -permeable cation channel expressed in gonadal somatic cells, is highly sensitive to ambient temperature and links environmental temperature to testicular differentiation in ricefield eel.
In female fish reared at cool temperature, injection of Trpv4 agonist into the ovaries leads to a significant upregulation of
5. 反例与边界
摘要未声明局限与反例——这是需要警惕的信号，精读时先问边界。
6. 跨领域连接与意外收获
思考本文机制能否迁移到你正在跟进的问题。
7. 可复用方法
把本文机制与你手头项目对照，找一个两周内能验证的最小实验。
8. 术语表
精读时把不熟的术语记入此处，作为下次回忆的锚点。