Genetic architecture of lipoma susceptibility implicates telomere biology
· 2026-09-09 · 原文
DOI：10.64898/2026.09.08.26362503v1?rss=1
Lipomas are common benign adipocytic neoplasms with well-characterized somatic cytogenetic alterations, but the inherited genetic architecture predisposing to their formation remains poorly understood. Recent phenome-wide evidence identified lipoma as strongly associated with genetic predisposition toward longer telomeres. Here, I examined this relationship from the complementary perspective of lipoma genetics. FinnGen R13 genome-wide association and native fine-mapping data resolved nine independent lipoma susceptibility signals across seven genomic regions. Unbiased annotation of these signals implicated telomere-maintenance and genome-stability genes, including telomerase reverse transcriptase (TERT), regulator of telomere elongation helicase 1 (RTEL1), and STN1 subunit of CST complex (
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1. 人话版
Lipomas are common benign adipocytic neoplasms with well-characterized somatic cytogenetic alterations, but the inherited genetic architecture predisposing to their formation remains poorly understood.
Recent phenome-wide evidence identified lipoma as strongly associated with genetic predisposition toward longer telomeres.
2. 领域脉络
Here, I examined this relationship from the complementary perspective of lipoma genetics.
3. 机制拆解
摘要未展开方法细节——精读时重点看方法/模型部分。
4. 证据与数字
FinnGen R13 genome-wide association and native fine-mapping data resolved nine independent lipoma susceptibility signals across seven genomic regions.
Unbiased annotation of these signals implicated telomere-maintenance and genome-stability genes, including telomerase reverse transcriptase (TERT), regulator of telomere elongation helicase 1 (RTEL1), and STN1 subunit of CST complex (
5. 反例与边界
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6. 跨领域连接与意外收获
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7. 可复用方法
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8. 术语表
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