Derivation and validation of clinical subphenotypes of adult sepsis in Africa: A latent class analysis of infection site and organ dysfunction
· 2026-09-08 · 原文
DOI：10.64898/2026.09.04.26362265v1?rss=1
Objective Sepsis is a heterogeneous syndrome characterized by substantial variation in infection source, organ dysfunction, and clinical outcomes, and a disproportionate burden in Africa. We aimed to derive and externally validate clinical subphenotypes among adults hospitalized with sepsis in Africa. Design We used latent class analysis with infection source and organ dysfunction as model inputs. We labeled classes post hoc according to their predominant clinical features. We evaluated associations between subphenotypes and 30-day mortality using multivariable logistic regression. Setting Hospitals in Uganda, Rwanda, Liberia, Tanzania, and Malawi. Patients We pooled data from three prospective cohorts of adults hospitalized with sepsis in Uganda, Rwanda, and Liberia for model derivation a
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1. 人话版
Objective Sepsis is a heterogeneous syndrome characterized by substantial variation in infection source, organ dysfunction, and clinical outcomes, and a disproportionate burden in Africa.
We aimed to derive and externally validate clinical subphenotypes among adults hospitalized with sepsis in Africa.
2. 领域脉络
Design We used latent class analysis with infection source and organ dysfunction as model inputs.
3. 机制拆解
We labeled classes post hoc according to their predominant clinical features.
4. 证据与数字
We evaluated associations between subphenotypes and 30-day mortality using multivariable logistic regression.
5. 反例与边界
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6. 跨领域连接与意外收获
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7. 可复用方法
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8. 术语表
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