Lifestyle therapy versus cognitive behavioural therapy for adults with mood disorders: a randomised non-inferiority trial
· 2026-09-10 · 原文
DOI：10.64898/2026.09.08.26362466v1?rss=1
Objective: To determine whether a multicomponent lifestyle intervention delivered by accredited dietitians and exercise physiologists was non-inferior to cognitive behavioural therapy (CBT) for reducing depressive symptoms in adults with moderate-to-severe mood disorders. Design: Randomised, parallel-group, single-blind, non-inferiority trial. Setting: Community-based recruitment across Australia with interventions delivered via telehealth. Participants: 358 adults with major depressive disorder or bipolar depression and moderate-to-severe depressive symptoms. Interventions: Lifestyle therapy versus brief structured CBT. Main outcome measures: Blinded interviewer-rated MADRS at 8 weeks with a prespecified non-inferiority margin of -1.6 points. Results: Mean session attendance was 5.11/7 in
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1. 人话版
Objective: To determine whether a multicomponent lifestyle intervention delivered by accredited dietitians and exercise physiologists was non-inferior to cognitive behavioural therapy (CBT) for reducing depressive symptoms in adults with moderate-to-severe mood disorders.
Design: Randomised, parallel-group, single-blind, non-inferiority trial.
2. 领域脉络
Setting: Community-based recruitment across Australia with interventions delivered via telehealth.
3. 机制拆解
Interventions: Lifestyle therapy versus brief structured CBT.
4. 证据与数字
Participants: 358 adults with major depressive disorder or bipolar depression and moderate-to-severe depressive symptoms.
Main outcome measures: Blinded interviewer-rated MADRS at 8 weeks with a prespecified non-inferiority margin of -1.6 points.
Results: Mean session attendance was 5.11/7 in
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