Realistic coupling enables flexible macroscopic traveling waves in the mouse cortex
· 2026-09-04 · 原文
Traveling waves are ubiquitous in neuronal systems across different spatial scales. While microscopic and mesoscopic waves are relatively well studied, the emergence of macroscopic traveling waves remains less understood. Here, by modeling the mouse cortex using spatial transcriptomic and connectivity data, we show that realistic cortical connectivity can generate a significantly higher level of macroscopic traveling waves than artificial local and uniform connectivity across multiple oscillation frequency bands, with the strongest advantage appearing in the theta, alpha, and beta frequency bands. By probing the model in different dynamic regimes, we find that macroscopic wave activity depends on both network connectivity and excitatory coupling strength, with a non-monotonic dependence on
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1. 人话版
Traveling waves are ubiquitous in neuronal systems across different spatial scales.
While microscopic and mesoscopic waves are relatively well studied, the emergence of macroscopic traveling waves remains less understood.
2. 领域脉络
Here, by modeling the mouse cortex using spatial transcriptomic and connectivity data, we show that realistic cortical connectivity can generate a significantly higher level of macroscopic traveling waves than artificial local and uniform connectivity across multiple oscillation frequency bands, with the strongest advantage appearing in the theta, alpha, and beta frequency bands.
3. 机制拆解
By probing the model in different dynamic regimes, we find that macroscopic wave activity depends on both network connectivity and excitatory coupling strength, with a non-monotonic dependence on
4. 证据与数字
摘要未给出量化结果——留意原文的实验与数据。
5. 反例与边界
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6. 跨领域连接与意外收获
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7. 可复用方法
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8. 术语表
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