Regional cardiac 31P-MRSI at 7T: detection of spatially heterogeneous patterns of myocardial energetic impairment
· 2026-09-09 · 原文
DOI：10.64898/2026.09.04.26362251v1?rss=1预印本：medRxiv开放获取：绿色OA
Background The phosphocreatine-to-ATP ratio (PCr/ATP), measurable by 31P magnetic resonance spectroscopic imaging (31P-MRSI), is a sensitive marker of myocardial energetic reserve. Regional energetic-mechanical coupling, evaluable only per-segment to avoid confounding from spatially heterogeneous disease, represents an important target for cardiac metabolic trials. We extend our previously validated 7T regional 31P-MRSI approach to patients with cardiovascular disease. Methods Twenty-one participants underwent same-day 7T 31P-MRSI and 3T CMR: 9 healthy volunteers, 4 with type 2 diabetes, 5 with heart failure, and 3 with ischaemic cardiomyopathy. PCr/ATP was mapped across six mid-ventricular AHA segments. Ejection fraction, global longitudinal strain, peak filling rate, and regional circumf
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1. 人话版
Background The phosphocreatine-to-ATP ratio (PCr/ATP), measurable by 31P magnetic resonance spectroscopic imaging (31P-MRSI), is a sensitive marker of myocardial energetic reserve.
Regional energetic-mechanical coupling, evaluable only per-segment to avoid confounding from spatially heterogeneous disease, represents an important target for cardiac metabolic trials.
2. 领域脉络
来源板块：板块一 · 研究前沿。
3. 机制拆解
PCr/ATP was mapped across six mid-ventricular AHA segments.
4. 证据与数字
We extend our previously validated 7T regional 31P-MRSI approach to patients with cardiovascular disease.
Methods Twenty-one participants underwent same-day 7T 31P-MRSI and 3T CMR: 9 healthy volunteers, 4 with type 2 diabetes, 5 with heart failure, and 3 with ischaemic cardiomyopathy.
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