Structural Brain Networks and the Seizure-Survival Paradox in Glioblastoma
· 2026-09-08 · 原文
DOI：10.64898/2026.09.04.26362299v1?rss=1
Background: In glioblastoma, tumor-related epilepsy (TRE) is paradoxically associated with longer survival, but the mechanism is unclear. We hypothesized that structural connectivity is associated with seizure susceptibility and survival, and tested whether these associations are independent or mediated. Methods: We retrospectively studied glioblastoma patients with preoperative diffusion-weighted MRI. Fractional anisotropy-weighted connectivity matrices were constructed using lesion-aware tractography. Mean edge weight and local efficiency were computed per Yeo 7-network and with global efficiency at hemisphere and whole-brain levels. Associations with TRE, overall survival (OS), and progression-free survival (PFS) were assessed using logistic regression and Cox proportional hazards model
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1. 人话版
Background: In glioblastoma, tumor-related epilepsy (TRE) is paradoxically associated with longer survival, but the mechanism is unclear.
We hypothesized that structural connectivity is associated with seizure susceptibility and survival, and tested whether these associations are independent or mediated.
2. 领域脉络
Methods: We retrospectively studied glioblastoma patients with preoperative diffusion-weighted MRI.
3. 机制拆解
Fractional anisotropy-weighted connectivity matrices were constructed using lesion-aware tractography.
4. 证据与数字
Mean edge weight and local efficiency were computed per Yeo 7-network and with global efficiency at hemisphere and whole-brain levels.
5. 反例与边界
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6. 跨领域连接与意外收获
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7. 可复用方法
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8. 术语表
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