Mitochondrial DNA Copy Number Is Associated With Visual Field Progression in Primary Open-Angle Glaucoma
· 2026-09-08 · 原文
DOI：10.64898/2026.09.05.26362328v1?rss=1
Purpose: To investigate the association between mitochondrial DNA (mtDNA) copy number (CN) and the rate of visual field progression in patients with primary open-angle glaucoma. Design: Retrospective cohort study Participants: 200 patients with primary open-angle glaucoma (POAG) with a mean of 11 years of longitudinal clinical data and DNA extracted from peripheral blood. Methods: DNA extraction was performed on peripheral blood leukocytes collected from 200 POAG patients who had an average follow-up of 11 years. Mitochondrial CN was quantified by multiplex quantitative TaqMan PCR using custom primers and probes against cytochrome b and beta-2 microglobulin as measures of mitochondrial and nuclear genes, respectively. Univariable and multivariable linear regression models were used to eval
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1. 人话版
Purpose: To investigate the association between mitochondrial DNA (mtDNA) copy number (CN) and the rate of visual field progression in patients with primary open-angle glaucoma.
Design: Retrospective cohort study Participants: 200 patients with primary open-angle glaucoma (POAG) with a mean of 11 years of longitudinal clinical data and DNA extracted from peripheral blood.
2. 领域脉络
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3. 机制拆解
Univariable and multivariable linear regression models were used to eval
4. 证据与数字
Methods: DNA extraction was performed on peripheral blood leukocytes collected from 200 POAG patients who had an average follow-up of 11 years.
Mitochondrial CN was quantified by multiplex quantitative TaqMan PCR using custom primers and probes against cytochrome b and beta-2 microglobulin as measures of mitochondrial and nuclear genes, respectively.
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