Deciphering Physiological and Pathological Influences on Amygdala-Hippocampus Connectivity
· 2026-09-08 · 原文
DOI：10.64898/2026.09.06.26362367v1?rss=1
Objective. Temporal lobe epilepsy (TLE) is associated with disrupted functional integrity in the amygdala-hippocampus complex. Cortico-cortical evoked potentials (CCEPs) can characterize this disruption and have been proposed as biomarkers of the epileptogenic zone (EZ), but their study is typically limited by the spatial sampling bias inherent to whole-brain intracranial EEG. We investigated how epileptogenicity shapes effective connectivity in the amygdala-hippocampus complex, whether structural connectivity underlies it, and ultimately derived a multimodal EZ biomarker. Methods. We retrospectively included 71 patients (50 adults, 21 children) who underwent single-pulse electrical stimulation protocols with intracranial contacts in the amygdala or hippocampus; 15 also underwent diffusion
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1. 人话版
Temporal lobe epilepsy (TLE) is associated with disrupted functional integrity in the amygdala-hippocampus complex.
Cortico-cortical evoked potentials (CCEPs) can characterize this disruption and have been proposed as biomarkers of the epileptogenic zone (EZ), but their study is typically limited by the spatial sampling bias inherent to whole-brain intracranial EEG.
2. 领域脉络
We investigated how epileptogenicity shapes effective connectivity in the amygdala-hippocampus complex, whether structural connectivity underlies it, and ultimately derived a multimodal EZ biomarker.
3. 机制拆解
摘要未展开方法细节——精读时重点看方法/模型部分。
4. 证据与数字
We retrospectively included 71 patients (50 adults, 21 children) who underwent single-pulse electrical stimulation protocols with intracranial contacts in the amygdala or hippocampus; 15 also underwent diffusion
5. 反例与边界
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6. 跨领域连接与意外收获
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7. 可复用方法
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8. 术语表
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