Glucose Dispersion Is Associated With Contrast Sensitivity Beyond Average Glycemia
· 2026-09-09 · 原文
DOI：10.64898/2026.09.08.26362509v1?rss=1预印本：medRxiv开放获取：绿色OA
Background: HbA1c and mean glucose summarize average glycemia but do not capture glucose dispersion. Whether free-living glucose dispersion is associated with visual function beyond average glycemia remains unclear. Aim: To determine whether glucose dispersion is associated with mesopic and photopic contrast sensitivity independently of HbA1c and contemporaneous CGM mean glucose. Methods: We analyzed 2,218 AI-READI participants with continuous glucose monitoring and visual-function data. Glucose dispersion was represented primarily by mean absolute deviation from mean glucose (AAD), and associations were assessed using multivariable linear regression. Results: Higher AAD was associated with lower mesopic and photopic contrast sensitivity after adjustment for age and HbA1c (beta = -0.188 an
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1. 人话版
Background: HbA1c and mean glucose summarize average glycemia but do not capture glucose dispersion.
Whether free-living glucose dispersion is associated with visual function beyond average glycemia remains unclear.
2. 领域脉络
来源板块：板块一 · 研究前沿。
3. 机制拆解
Glucose dispersion was represented primarily by mean absolute deviation from mean glucose (AAD), and associations were assessed using multivariable linear regression.
4. 证据与数字
Aim: To determine whether glucose dispersion is associated with mesopic and photopic contrast sensitivity independently of HbA1c and contemporaneous CGM mean glucose.
Methods: We analyzed 2,218 AI-READI participants with continuous glucose monitoring and visual-function data.
Results: Higher AAD was associated with lower mesopic and photopic contrast sensitivity after adjustment for age and HbA1c (beta = -0.188 an
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