Posttraumatic Stress Disorder Epigenome-Wide Association Studies in the Million Veteran Program
· 2026-09-08 · 原文
DOI：10.64898/2026.09.04.26362177v1?rss=1
Genomic studies have improved our understanding of posttraumatic stress disorder (PTSD) biology. Epigenetic differences in DNA methylation can reflect environmental influences, which are critical in PTSD etiology, and may additionally differentiate between PTSD cases and controls or distinguish severity of PTSD symptoms. We conducted PTSD epigenome-wide association studies (EWAS) in a large cohort, n = 22,141 subjects from the United States V.A. Million Veteran Program (MVP), with the PTSD Checklist (PCL-17), including 17,674 European ancestry (EUR), 3,430 African ancestry (AFR), and 1,037 admixed American descent (AMR). We evaluated the 17-item PCL-Total as well as symptom subdomains (re-experiencing, avoidance, and hyperarousal), and used lasso regression on electronic health records to
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1. 人话版
Genomic studies have improved our understanding of posttraumatic stress disorder (PTSD) biology.
Epigenetic differences in DNA methylation can reflect environmental influences, which are critical in PTSD etiology, and may additionally differentiate between PTSD cases and controls or distinguish severity of PTSD symptoms.
2. 领域脉络
来源板块：板块一 · 研究前沿。
3. 机制拆解
摘要未展开方法细节——精读时重点看方法/模型部分。
4. 证据与数字
We conducted PTSD epigenome-wide association studies (EWAS) in a large cohort, n = 22,141 subjects from the United States V.A.
Million Veteran Program (MVP), with the PTSD Checklist (PCL-17), including 17,674 European ancestry (EUR), 3,430 African ancestry (AFR), and 1,037 admixed American descent (AMR).
We evaluated the 17-item PCL-Total as well as symptom subdomains (re-experiencing, avoidance, and hyperarousal), and used lasso regression on electronic health records to
5. 反例与边界
摘要未声明局限与反例——这是需要警惕的信号，精读时先问边界。
6. 跨领域连接与意外收获
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7. 可复用方法
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8. 术语表
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