Prepubertal Body Mass Index Reshapes the Distribution of Pubertal Growth Velocity in Vietnamese Children: A SITAR-Based Quantile Analysis

· 2026-09-08 · 原文

DOI：10.64898/2026.09.04.26362313v1?rss=1

Background: Prepubertal body mass index (BMI) has been reported to associate with pubertal growth spurts, but whether BMI reshapes the entire distribution of pubertal growth, not just its average, is unknown, particularly in Southeast Asian children. Methods: We studied 8,018 boys, 5,495 girls from the 2018-2025 cohort of schoolchildren in 3 major cities in Vietnam with SITAR derived growth curves and prepubertal BMI z scores. Individual height SITAR size, timing, and intensity (velocity) parameters was modeled with linear quantile mixed models across quantiles 0.05 to 0.95, separately by sex, with a sensitivity model re-centered on each child's own age at peak height velocity. Results: In boys, the BMI to velocity association reversed across the distribution, from 0.045 cm/year per SD at

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Methods: We studied 8,018 boys, 5,495 girls from the 2018-2025 cohort of schoolchildren in 3 major cities in Vietnam with SITAR derived growth curves and prepubertal BMI z scores.

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Individual height SITAR size, timing, and intensity (velocity) parameters was modeled with linear quantile mixed models across quantiles 0.05 to 0.95, separately by sex, with a sensitivity model re-centered on each child's own age at peak height velocity.

Results: In boys, the BMI to velocity association reversed across the distribution, from 0.045 cm/year per SD at

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