In vitro sexual dimorphism establishment in schistosomes
· 2026-09-10 · 原文
Schistosomes are parasitic flatworms that cause Schistosomiasis, a major neglected tropical disease that affects more than 250 million people worldwide. With two distinct sexes, a heterogametic female (ZW) and a homogametic male (ZZ), schistosomes are an exception among flatworms, which are largely hermaphroditic. Sexual dimorphism in schistosomes only becomes apparent by adulthood within the mammalian host. However, the cellular and molecular mechanisms underlying the sexual differentiation of are poorly understood, partly due to intrinsic challenges in assessing parasite development in vivo. Therefore, robust and reproducible approaches for maintaining and developing parasites in vitro are needed to overcome these difficulties. To date, few studies have focused on protocols that allow cu
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1. 人话版
Schistosomes are parasitic flatworms that cause Schistosomiasis, a major neglected tropical disease that affects more than 250 million people worldwide.
With two distinct sexes, a heterogametic female (ZW) and a homogametic male (ZZ), schistosomes are an exception among flatworms, which are largely hermaphroditic.
2. 领域脉络
来源板块：板块二 · 顶级期刊。
3. 机制拆解
Therefore, robust and reproducible approaches for maintaining and developing parasites in vitro are needed to overcome these difficulties.
4. 证据与数字
摘要未给出量化结果——留意原文的实验与数据。
5. 反例与边界
Sexual dimorphism in schistosomes only becomes apparent by adulthood within the mammalian host.
However, the cellular and molecular mechanisms underlying the sexual differentiation of are poorly understood, partly due to intrinsic challenges in assessing parasite development in vivo.
6. 跨领域连接与意外收获
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7. 可复用方法
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8. 术语表
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